Trivarol

Drugs , Vitamins and Minerals / November 11, 2016

Class: Vitamins and Minerals
Dosage Form: Various
Stock: Available
Manufacturer: Memphis Co.

Composition:

Tablets:
Active Ingredients
Thiamine hydrochloride (Vitamin B1)…………….125 mg
Pyridoxine hydrochloride (Vitamin B6)…………..125 mg
Cyanocobalamine (Vitamin B12)……………………..125 µg
Folic acid………………………………………………………0.5 mg
Excipients
Polyvinyl pyrilidone, Talc, Magnesium stearate, Starch, Colloidal silicon dioxide

Ampoules:
a) Each 1 ml of Ampoule A contains:
Active Ingredients
Thiamine hydrochloride (Vitamin B1)…………….100 mg
Pyridoxine hydrochloride (Vitamin B6)……………25 mg
Excipients
Sodium acid phosphate, sodium versenate, thiourea
b) Each 1 ml of Ampoule B contains:
Active Ingredients
Cyanocobalamine (Vitamin B12)……………………….1 mg
Excipients
Citric acid monohydrate, dibasic sodium phosphate anhydrous, probyl paraben base

Properties:

Vitamin B1 combines with ATP (Adenosine triphosphate) to form thiamine pyrophosphate, known as co-carboxylase, a coenzyme, which catalyzes the decarboxylation of pyruvic acid and other keto acids.
Vitamin B6 acts as a coenzyme in the metabolism of proteins, carbodyhdrates and fats. It participates in the decarboxylation and transasmination of amino acids and is responsible for the breakdown of glycogen to glucose-1-phosphate.
Vitamin B12 is essential for growth, cell reproduction, hematopoiesis and synthesis of nucleoprotein and myelin.
Folic acid is required for nucleoprotein synthesis and maintenance of normal erythropoiesis. Folic acid stimulates the production of red and white blood cells, as well as, platelets.

Indications:

Trivarol is indicated in:

  • Painful neuritis
  • In-born errors of metabolism
  • Inadequate dietary intake
  • Pernicious anemia
  • Hemolytic anemia and cases of increased vitamin requirement, such as pregnancy
  • Treatment of megaloblastic anemia

Contraindicatons:

A history of sensitivity to any component of the product.

Drug Interactions:

The following interactions are to be noted:

  •  Vitamin B6 increases the peripheral metabolism of levodopa
  • Chloramphenicol may antagonize the hematopoietic response to vitamin B12
  • Colchicine, aminoglycosides, certain anticonvulsants e.g. (phenytoin, Phenobarbital) and para-aminosalicylic acid may impair the absorption of vitamin B12

Side Effects:

Mild transient diarrhea and itching have been reported.

Dosage and Administration:

The following is generally recommended:

  • Tablets: 1 tablet three times daily, or as directed by the physician
  • Ampoules: One ampoule (A+B) daily or as prescribed by the physician

Packaging:

Pack of 2 strips of 10 tablets each.

Storage:

Store at room temperature, below 25°C.

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