Prazolam

Class: Central Nervous System
Dosage Form: Tablets
Stock: Available
Manufacturer: Eva Pharma

Composition:

Alprazolam………………0.25, 0.5 mg

Properties:

Alprazolam is a short acting benzodiazepine which possesses antidepressant activity, it exerts its anxiolytic effect by binding at the stereo specific receptors within the central nervous system.
Alprazolam is well absorbed from the gastrointestinal tract following oral administration.

Indications:

Prazolam is indicated in:

  • Treatment of  anxiety states (anxiety neuroses)
  • Anxiety associated with depression
  • Treatment of panic disorder

Contraindicatons:

Prazolam is contraindicated in:

  • Known sensitivity to Alprazolam or other benzodiazepines
  • Patients with acute narrow glaucoma
  • Respiratory insufficiency

Drug Interactions:

The following interactions are reported:

  • Delayed clearance of alprazolam occurs when co-administered with cimetidine and some oral contraceptives
  • Reduced clearance of digoxin when co-administered with alprazolam resulting in raised serum concentration of digoxin

Side Effects:

Drowsiness, light-headedness, sedation and ataxia, symptoms usually subside with continuous use of medication.
Rarely: Headache, confusion, blurred vision, slurred speech, abdominal cramps, dry mouth, palpitations and respiratory depression.

Dosage and Administration:

Treatment duration should not exceed eight months.

  • For anxiety or nervous tension:
    • Initial: 0.25 mg. to 0.5 mg three times daily
    • Maximum: 4 mg in 24 hours
  • For anxiety associated with depression:
    • Initial: 0.5 mg given three times daily
    • Maximum: 4.5 mg daily given in divided doses
  • For panic disorder:
    • Initial: 0.5 mg to 1 mg given at bedtime or 0.5 mg three times daily

The dose should be adjusted according to patient response.
Dosage adjustments should be in increments no greater than 1 mg every three to four days.

  • Elderly patients, patients with advanced liver diseases and patients with debilitating diseases: Initial dose is 0.25 mg given two to three times daily

Pregnancy and Lactation:

Benzodiazepines are generally not recommended during pregnancy or in women of childbearing potential.

Warnings:

Avoid consumption of alcohol and concomitant use of CNS depressants.
Caution should be exercised while driving or operating hazardous machinery.
Risk of dependence with high doses (4 mg for more than 8-12 weeks), some risk of dependence may occur even with relatively short term use at the recommended dose of 0.75 to 4 mg per day.
Withdrawal or reduction of alprazolam doses should be gradual and under medical consultation.
Not recommended for ages under 18.
Alprazolam is excreted in human milk and is not indicated for nursing mothers.

Packaging:

Box of 2 strips, each of 10 tablets.

Storage:

Store at room temperature, below 25°C.

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