Oxazacin

Central Nervous System , Drugs / October 9, 2016

Class: Central Nervous System
Dosage Form: Tablets
Description: Anxiolytic and hypnotic
Stock: Out of Stock
Manufacturer: N/A

Composition:

Oxazepam…………10 mg

Properties:

Oxazepam is a benzodiazepine which exerts its pharmacological effect at the site of the GABA synapse increasing the affinity of the receptor for GABA thus reducing GABA turnover, which is a major inhibitory transmitter in the CNS.

Indications:

Oxazacin is indicated in:

  • Oxazepam is used in management of anxiety or for the short-term relief of the symptoms of anxiety
  • Anxiety, tension, agitation, and irritability in older patients
  • Anxiety associated with depression.

Contraindicatons:

Oxazacin is contraindicated in:

  • Hypersensitivity to oxazepam
  • Oxazepam is contraindicated in psychoses
  • Oxazepam is contraindicated during pregnancy or lactation
  • Not indicated for pediatric use

Drug Interactions:

Alcohol or other CNS depressant drugs may increase the effect of oxazepam.

Side Effects:

The following side effects are to be noted:

  • Mild drowsiness is commonly seen in the first few days of therapy
  • Rare instances of minor diffuse skin rashes, urticaria, nausea, edema, slurred speech, tremors and altered libido
  • Mild paradoxical reactions have occurred
  • Such side effects have been infrequent and are generally controlled with reduction of dosage

Dosage and Administration:

The following dosage is generally recommended:

  • Mild to moderate anxiety with associated tension, irritability, agitation, or related symptoms of functional origin or secondary to organic disease: 10 to 15 mg 3 or 4 times daily
  • Severe anxiety syndromes, agitation, or anxiety associated with depression: 15 to 30 mg 3 or 4 times daily
  • Older patients with anxiety, tension, irritability and  agitation: initial dose 10 mg 3 times daily, to be increased, if necessary, according to physician’s directions up to 15 mg 3 or 4 times daily
  • Alcoholics with acute inebriation, tremulousness or anxiety on withdrawal:15 to 30 mg, 3 or 4 times daily

Pregnancy and Lactation:

Oxazepam is contraindicated during pregnancy or lactation.

Warnings:

Patients should avoid driving vehicles or operating machinery because the product may cause drowsiness.
The drug should be withdrawn gradually.
Benzodiazepines may produce psychological & physical dependence, it is advisable that patients consult with their physician before either increasing the dose or abruptly discontinuing the drug.
Periodic blood counts & liver function tests are desirable.
Oxazepam should be administered cautiously to patients whose blood pressure drop may lead to cardiac complication.

Storage:

Store at room temperature, below 25°C.

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