Drugs , Respiratory System / November 18, 2016

Class: Respiratory System
Dosage Form: Syrup
Description: Antihistaminic and antitussive syrup
Stock: Available
Manufacturer: Amriya Pharmaceuticals


Each 100 ml contains:
Active Ingredients
Oxomemazine……………..0.033 g
Guaifenesin…………………0.666 g
Sodium benzoate…………0.666 g
Paracetamol………………..0.666 g
Glycerol, Citric acid monohydrate, Sodium citrate dihydrate, Caramel flavor, Caramel flavor, Sucrose and Purified water


Oplex is a combination of substances which contains an antihistamine, antitussive and sedative (Oxomemazine), two expectorants (Guaifenesin and Sodium benzoate) and antipyretics (Paracetamol).

Guaifenesin is absorbed from the gastrointestinal tract. It is metabolized and then excreted in the urine.
Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral doses and is distributed into most body tissues. It crosses the placenta and is present in breast milk. Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol.
Sodium benzoate is absorbed from the gastrointestinal tract and conjugated with glycine in the liver to from hippuric acid, which is rapidly excreted in the urine.


Oplex is indicated in treatment of dry and wet cough, including allergies and irritants.


Oplex should not be used in cases of respiratory or hepatic insufficiencies.

Drug Interactions:

Oplex may interact with other sedatives or atropine.

Side Effects:

The following side effects are to be noted:

  • Sleepiness
  • Digestive disorders
  • Thickening of the bronchial secretions
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urine retention
  • Mental confusion in the elderly
  • Agitation in children

Dosage and Administration:

Treatment should not exceed a few days.
The use of this medication must be distributed during the day.

1. Adults:

  • 1 or 2 teaspoons of syrup, 2 or 3 times a day
  • In the elderly, starting with the lowest dose

2. Children:

  • To 30 months: 1 to 3 teaspoons of syrup per day, in 2 or 3 divided doses
  • Above 30 months: 3 to 5 teaspoons of syrup per day, in 2 or 3 divided doses

Pregnancy and Lactation:

The effect of this medicine during pregnancy or lactation is poorly understood. The evaluation of possible risks associated with its use is individual.


Oplex is not intended for use in children under 6 years without medical advice.
Do not use this medicine in children under 2 years.
Cough is a symptom that can reveal many diseases and a physician should be consulted if it persists for more than a few days.Oplex contains sucrose in a significant quantity, so it is not intended to be used in patients with diabetes mellitus.
Oplex contains paracetamol, which must be taken into consideration when taken alongside other medications containing the ingredient.
Alcoholic beverages should be avoided due to increased risk of drowsiness.
Operation of heavy machinery or driving should be done with caution due to possibility of drowsiness or impaired alertness with use of Oplex.


Carton box containing a bottle of 125 ml syrup.


Store at room temperature, below 25°C.

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