Drugs , Vitamins and Minerals / October 17, 2016

Class: Vitamins and Minerals
Dosage Form: Various
Description: Neurotropic
Stock: Out of Stock
Manufacturer: Merck Serono


Vitamin B1 (thamine disulfide)……………………..100 mg
Vitamin B6 (pyridoxol hydrochloride)…………..200 mg
Vitamin B12 (cyanocobalamin)……………………..200 µg

Ampoule (3 ml):
Thiamine hyrdrocholoride (Vitamin B1)………..100 mg
Pyridoxine hydrocholoride (Vitamin B6)……….100 mg
Cyanocobalamin (Vitamin B12)…………………..1000 µg


The vitamins B1, B6, and B12 are indispensable for a normal course of the nervous metabolism.
Neurobion coated tablets are prescribed in neuralgia, pain in the spinal region, migraine and circulation disorders.


Neurobion is indicated for the prevention and treatment of vitamins B1, B6 or B12 deficiency; and their prophylaxis, e.g. in neurological and other disorders associated with disturbances of the metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis, polyneuropathy of pregnancy, toxemia of prgnancy, nausea and vomiting of pregnancy, post-influenzal neuropathies.
Neurobion is also recommended for the treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back-pain, ischialgia, and herpes zoster.


Neurobion should not be used in:

  • Patients on levodopa therapy
  • Hypersensitivity to any of the product ingredients
  • Injections should not be used in newborns, especially in premature infants

Drug Interactions:

Patients under levodopa medication should not receive drugs with high amounts of vitamin B6 (pyridoxine), as the former leads to a reduction in the dopa effect; this applies also to Neurobion due to its content of vitamin B6.

Side Effects:

Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord.
Cyanocobalamin is not a suitable form of vitamin-B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.
In individual cases sweating, tachycardia, and skin reactions accompanied by itching and urticaria have been described. In rare cases, hypersensitivity reactions may occur; e.g. After parenteral application of vitamin B1 exanthemes, difficulties to breathe, and conditions of shock may occur.
In individual cases, drug-induced eczema and uritcaria have been reported after parenteral administration of vitamin-B12.

Dosage and Administration:


  • Unless otherwise prescribed by the physician, 1-2 coated tablets of Neurobion three times daily
  • Larger doses, if required should be taken according to medical instruction
  • No sign of hypervitaminosis were noted
  • The coated tablets are swallowed, unchewed, with a little liquid during or after meals

2. Ampoules:

  • Initially, 1 ampoule per day given intramuscularly until improvement of clinical symptoms
  • After cessation of symptoms, 2 or 3 times weekly; in less severe cases, this dosage my already be sufficient
  • During days free of injections, or as continuation therapy with injection solution, coated tablets are available
  • The duration of treatment is determined by the physician


Box of 20 coated tablets.
Box of 3 or 6 ampoules of 2 ml each.


Store at room temperature, below 25°C.

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