Lamotrine

Central Nervous System , Drugs / November 8, 2016

Class: Central Nervous System
Dosage Form: Tablets
Description: Antiepileptic
Stock: Available
Manufacturer: Multi-Apex Pharma

Composition:

Lamotrigine is an antiepileptic drug. It acts through blockage of voltage-sensitive sodium channels to stabilize the neuronal membranes. This results in inhibition of excitatory amino acids during epileptogenesis.
Lamotrigine acts on neurones displaying epileptiform activity and has no effect on normal neuronal activity.
Lamotrigine is rapidly and completely absorbed after oral intake. Oral bioavailability is 98%, protein binding is 55% and half-life is 24-35 hours.

Indications:

Add-on Therapy:
It is indicated as add-on therapy in partial and generalized seizures and the seizures associated with Lennox-Gastaut syndrome in pediatric and adult patients.
Monotherapy:
It is indicated for conversion to monotherapy in adults with partial seizures who are receiving treatment with single EIADEs (enzyme-inducing antiepileptic drugs).

Contraindicatons:

Hypersensitivity to lamotrigine.

Side Effects:

Headache, nasusea, dizziness, insomnia, ataxia, diplopia, blurred vision and coordination abnormalities.
Weight decrease, chest pain, dysmenorrhea and anxiety are infrequent side effects.

Dosage and Administration:

1.Lamotrine added to an AED regimen containing valproate in patients over 12 years of age:

  • Weeks 1&2: 25 mg every other day.
  • Weeks 3&4: 25 mg every other day.

Usual maintenance dose: 100-400 mg/day (1 or 2 divided doses). To achieve maintenance, doses may be increased by 25-50 mg/day every 1 to 2 weeks.
Usual maintenance dose in patients adding Lamotrine to valproate alone ranges from 100-200 mg/day.

2. Lamotrine added to EIADs (without valproate) in patients over 12 years of age:

  • Weeks 1&2: 50 mg/day.
  • Weeks 3&4: 100 mg/day, in 2 divided doses.

Usual maintenance dose is 300-500 mg/day (in 2 divided doses). To achieve maintenance, doses may be increased to 100 mg/day every 1-2 weeks.
The recommended maintenance dose of Lamotrine as monotherapy is 500 mg/day given in divided doses.
Dose for children with Lenox Gastaut syndrome is from 100-300 mg/day.

Warnings:

Lamotrigine should be discontinued at first sign of rash, unless the rash is clearly not drug related.
It should not be used for simultaneous conversion from two or more AED (anti-epileptic drugs).
It should not be used for conversion from non-EIAEDs (as valproate).

Packaging:

Pack of 3 strips of 10 tablets each.

Storage:

Store at room temperature, below 25°C.

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