Flumox

Antibacterials , Drugs / November 17, 2016

Class: Antibacterials
Dosage Form: Various
Description: Broad-spectrum antibiotic
Stock: Available
Manufacturer: EIPICO

Composition:

Tablets:
Active Ingredients
Amoxycillin trihydrate………………………………………..500 mg
Flucolxacillin sodium monohydrate……………………..500 mg
Excipients
Polyvinlylpyrrolidone (Povidone K 30), crospovidone, microcrystalline cellulose PH101, colloidal silicon dioxide (Aerosil 200), magnesium stearate

Capsules:
Active Ingredients
Amoxycillin trihydrate……………………………….125 or 250 mg
Flucolxacillin sodium monohydrate……………125 or 250  mgExcipients
Maize starch, micrcyrstalline cellulose, purified talc, colloidal silicon dioxide, mangesium stearate

Suspension: (5 ml)
Active Ingredients
Amoxycillin trihydrate…………………………………………125 mg
Flucolxacillin sodium monohydrate………………………125 mg
Excipients
Colloidal silicon dioxide, carboxy methylcellulose sodium, lactose, propyl para-hydroxybenzoate, sodium citrate anyhydrous, sucrose, cherry flavor oil, saccharin sodium, sodium cyclamate, veltol plus, avicer RC 591

Properties:

Pharmacodynamics
Flumox is a combination of two semi-synthetic penicillins: amoxycillin (broad-spectrum penicillin) and flucloxacillin (a penicillinase-resistant penicillin). This combination exhibits a bacterial activity against wide range of gram-positive and gram-negative microorganisms.
Flumox exerts a bactericidal action on penicillinase-producing and non-penicillinase-producing Staphylococci, Streptococcus pyogenes, pneumoniae, and faecalis. Corynebacterium diphtheriae, Clostridia spp., Bacillus anthracis, H. influenzae, Moraxella (Branhamella) catarrhalis, N. gonorrhea and meningitidis, E. coli, Proteus mirabilis, Salmonella, Bordetella pertussis, and Bacteriodes mleaningogenicus.

Pharmacokinetics
Both amoxycillin and flucloxacillin are acid-stable and are well-tolerated after oral administration. Amoxycillin is more rapidly absorbed than ampicillin producing higher plasma concentrations than those obtained with the same dose of ampicillin.
Peak plasma concentrations of amoxycillin and flucloxacillin are achieved after 1 to 2 hours. Amoxycillin and flucloxacillin are metabolized to a limit extent, and the unchanged drugs are metabolites are excreted in the urine by glomerular filtration and renal tubular secretion.

Indications:

Flumox is indicated in the treatment of a wide range of infections including:

  • Respiratory tract infections:
    • Bronchitis
    • Penumonia
    • Empyema
  • Ear, Nose and Throat infections:
    • Otitis media
    • Sinusitis
    • Tonsilitis
    • Pharyngitis
  • Gastro-intestinal tract infections:
    • Enteritis
    • Cholecystitis
    • Typhoid and paratyphoid
    • Peritonitis and intra-abdominal abscesses
    • Biliary tract infections
  • Gentio-urinary infections:
    • Cystitis
    • Pyelonephritis
    • Prostatitis
    • Gonorrhea
    • Puerperal sepsis
  • Skin and soft-tissue infections:
    • Post-operative wound infections
    • Boils
    • Carbuncles
    • Abscesses
    • Cellulitis
  • Bone infections:
    • Osteomyelitis
  • Other infections:
    • Septicemia and endocarditis

Contraindicatons:

Known hypersensitivity to penicillin.

Drug Interactions:

Concomitant administration of amoxycillin and anticoagulants from the coumarin class, may prolong the bleeding time. A dose adjustment of anticoagulants may be necessary.

Side Effects:

As with other penicillins, side-effects are usually infrequent, mild and transient including dairrhea, indigestion, and skin rashes.

Dosage and Administration:

The following is generally recommended:
1. Adults:

  • The usual oral dose is Flumox 250, 500 or 1000 mg every 8 hours

2. Children up to 10 years of age:

  • They may be given 125 to 250 mg every 8 hours

3. For those under 40 kg:

  • A dose of 20 to 40 mg/kg daily in divided doses every 8 hours, or 25 to 45 mg/kg daily in divided doses every 12 hours, may be used

4. In infants less than 3  months old:

  • The maximum dose should be 30 mg/kg daily in divided doses every 12 hours

5. Reconstitution of Flumox Dry Mix:

  • To make up first shake the bottle to loosen the powder, then add the volume of water stated on carton box to the contents of the bottle
  • Shake well
  • Once reconstituted, Flumox must be stored in a refrigerator and used within 10 days

Warnings:

Doses should be reduced in severe renal impairment.

Packaging:

Flumox 1 g tablets contained in 3 strips of 5 tablets each.
Flumox 250 or 500 mg tablets in 2 strips of 6 capsules each.
Flumox dry mix bottle of powder to make 100 ml suspension after reconstitution.

Storage:

Store at room temperature, below 25°C.

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