Tradename
Olfen-75
Generic Name
Diclofenac sodium, Lidocaine hydrochloride
Category
Musculoskeletal System
Form
Ampoule
Composition
Diclofenac sodium.................75 mg
Lidocaine hydrochloride..........20 mg
Description
Antirheumatic, anti-inflammatory and analgesic
Properties/Actions
Pharmacodynamics
Olfen (diclofenac) belongs to nonsteroidal anti-inflammatory group of drugs and exhibits marked anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties.
Olfen inhibits prostaglandin synthetase, thus reducing prostaglandins that have a major role in generation of inflammation, pain and fever.
Olfen is thus suitable for the treatment of rheumatic states, non-rheumatic inflammatory conditions and pain.
In rheumatic conditions, the anti-inflammatory and analgesic properties of Olfen injection induce relief of pain at rest, of pain on movement, of morning stiffness and swelling of the joints in addition to improvement in function.
In post-traumatic and post-operative inflammatory conditions, Olfen ampoules relieve pain and decrease inflammatory swelling and edema. It was found that Oflen ampoules have a remarkable analgesic effect in moderate to severe pain which was not of rheumatic origin. This analgesic effect is seen within 15-20 minutes.
Oflen ampoules have a novel pharmaceutical presentation of Diclofenac sodium as 75 mg of Diclofenac, in addition to 20 mg of Lidocaine hydrochloride that are present in only 2 ml total injection volume. This ensures that Olfen injections are less painful and possess better local tolerance.

Pharmacokinetics
Approximately 20 minutes after intramuscular injection of 75 mg Diclofenac, a mean peak plasma concentration of 2.5 μg/ml (8 μmol/litre) is attained. The plasma concentration is in linear relation to the size of the dose.
The area under the concentration curve (AUC) is about twice as large as it is following oral or rectal administration of a dose of equal size, because about half the active substance is metabolized during its first passage through the liver ("first pass" effect). The terminal half-life in plasma is 1-2 hours.
Indications
Contraindications
Olfren must not be used in presence of:
  • Peptic ulcer
  • pregnancy and lactation
  • Hypersensitivity (e.g. with asthma attacks, skin reactions, acute rhinitis) to acetylsalicylic acid or other nonsteroidal anti-inflammatory agents
  • Severe disorders of the liver function or haemopoiesis disorders
Drug Interactions
The simultaneous use of Olfen with lithium or digoxin products increases the lithium or the digoxin levels in the blood.
In the case of simultanenous treatment with potassium-sparing diuretics, particular monitoring of serum potassium levels is required since Olfen, like other nonsteroidal anti-rheumatics, can lead to an increase in potassium values (hyperpotassaemia).
The simultaneous administration of corticosteroids or other anti-inflammatory agents increases the risk of gastrointestinal bleeding.
An inhibition of the action of diuretics such as furosemide or ethacrynic acid is possible, as is a weakening of the action of antihypertensive drugs.
The simultaneous administration of acetylsalicylic acid leads to a decrease in the blood concentration of the active agent diclofenac.
Side Effects/Adverse Effects
Gastrointestinal upsets, upper abdominal pain, eructation, nausea, diarrhea, light-headedness or headaches at the start of treatment.
These adverse effects are generally mild and usually regress after a few days. Hypersensitivity reactions such as skin rash and pruritus, asthma attacks and a tendency to edema mary arise.
Pregnancy & Lactation
Dosage & Administration
Adults:
The injecton solution is generally injected once daily as a deep intragluteal injection in the upper external quadrant.
With severe pain states, up to two injections per day can be given with an interval of several hours, changing the injection sites.
A change is made to Lactab tablets after the severe pain has faded.
Overdosage
Warnings
Patients with evidence of peptic ulcer in their history, those with unexplained gastrointestinal disorders, those with liver or kidney damage, and those with high blood pressure as well as elderly patients require attentive medical supervision.
Patients who suffer from asthma, hay fever, nasal polyps or chronic airways infections, and patients with hypersensitivity to analgesics and rheumatic durgs of all types are threatened with asthma attacks when using Olfen (so-called analgeisc intolerance, analgesic-induced asthma).
Notes
Storage
Packaging
Boxes of 3 or 6 ampoules of 2 ml.
Manufacturer
Medical Union Pharmaceuticals
Price
Date Added/Updated
1st January 2012 10:14 pm

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