Generic Name
Endocrine System
Metformin HCl...........500 or 1000 mg
Retard Tablet:
Metformin HCl.......................850 mg
Biguanide oral hypoglycemics.
  • Cidophage contains metformin HCl which is a biguanide oral antidiabetic used in management of type II (non-insulin dependent diabetes mellitus).
  • Cidophage is the drug of first choice in obese diabetics with insulin resistance syndrome alone or with sulphonylurea.
  • Cidophage has hypolipidemic effects, lowering serum triglycerides, LDL cholesterol level without any adverse effect on other lipid levels. Cidophage stabilizes or decreases body weight; its anorexic effect is beneficial in weight loss.
  • Cidophage exerts its action as antihyperglycemic agent without cauing hypoglycemia and without weight gain.
  • Cidophage improves insulin sensitivity withotu causing hyperinsulinemia.
  • Cidophage exerts its action by decreasing gluconeogenesis, reducing intestinal absorption of glucose and increasing peripheral glucose uptake and utilization by skeletal muscles.
  • Cidophage reaches maximal plasma concentration after 1-2 hours, it is not bound to plasma protein, and not metabolized and excreted unchange in urine.
  • For non-insulin dependent diabetes mellitus (type II) alone or with sulphonylurea.
  • Overweight diabetics.
  • Polycystic ovary syndrome, as sole therapy or as an adjuvant to clomiphene.
  • Ketoacidosis and hypoxic states (e.g. respiratory failure, recent myocardial infarction).
  • Renal or hepatic impairment.
  • Congestive heart failure.
  • Use of iodinated x-ray contrast media (restart after renal function is verified normal).
  • Known hypersensitivity to metformin.
Drug Interactions
  • Drugs that may diminish the hypoglycemic effect: Corticosteroids, oral contraceptives, estorgen, thyroid products, sympathomimetics and calcium channel blockers.
  • Drugs that may enhance the hypoglycemic effect: Alcohol, furosemide, nifedipine and cimetidine.
Side Effects/Adverse Effects
  • Transient GIT disturbances (e.g. anorexia, nausea, diahrrea) which resolve spontaneously during continuous treatment (overcome by taking Cidophage with meals).
  • Lactic acidosis may rarely occur due to metformin accumulation so caution must be taken.
  • Dermal rash and dermatitis may rarely occur.
Pregnancy & Lactation
It is warned against the use of Cidophage in pregnancy, although it does not cross the placental barrier and there is no evidence of teratogenic effects.
Dosage & Administration
  • Intially, 500 mg daily increased gradually to a maximum of 2.5 g daily with or after meals in divided doses or according to doctor's supervision.
  • Cidophage-retard 850 mg: 1-2 tablets morning and evening with meals.
  • Medical and surgical emergencies - substitute with insulin.
  • Cidophage may decrease intestinal absorption of Vit. B12, so parenteral Vit. B12 adminstration is advisable. Also, red blood cell parameters should be monitored once per year. 
  • For patients receiving other hypoglycemic agents, dose adjustment of both Cidophage and the other medication is a must.
  • Store below 30°C and R.H. below 70%.
  • Cidophage 500 or 1000 mg: Strips of 10 tablets.
  • Cidophage retard 850 mg: Boxes of 30 or 60 tablets.
Chemical Industries Development (Egypt)
Date Added/Updated
6th April 2011 4:51 pm


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