Tradename
Septazole
Generic Name
Sulphamethoxazole and Trimethoprim
Category
Antimicrobials
Form
Various
Composition
Tablets:
Sulphamethoxazole..............400 mg
Trimethoprim........................80 mg
Suspension (5ml):
Sulphamethoxazole..............200 mg
Trimethoprim........................80 mg
Description
Broad spectrum antibitoic.
Properties/Actions
Septazole is bactericidal chemotherapeutic ageint with a wide spectrum comparable with that of ampicillin, chloramphenicol and tetracycline.
The constituents of Septazole have a sequential effect on the conversion of folic acid to its biologically active form, tetrahydrochloric acid. Sulphamethoxazole inhibits the enzyme dihydropteroate reductase, which catalyses the reduction of folic acid to dihydrofolic acid, whilst trimethoprim prevents the reduction of dihydrofolic acid to tetrahydrofolate by competitive inhibition of dihydroreductase. About 85% of ingested Sulphamethoxazole is absorbed, while trimethoprim is completely absorbed. Mean plasma half life of sulphamethoxazole is 9 hours, while that of trimethoprim is 10 hours.
Sulphamethoxazole has good distribution, penetrating the brain, prostate, lungs, CSF, aqueous humor. It is 66% bound to plasma proteins.
Both sulphamethoxazole and trimethoprim are excreted in the breast milk and cross the placenta and eliminated in the urine.
Indications
Septazole is an antibacterial agent indicated in the treatment of the following infections:
  • Respiratory tract: Acute and chronic bronchitis, bronchiectasis, lobar and bronchopneumonia, otits media and sinusitis.
  • Gentio-urinary tract: Urethritis, cysitis, pyelitis, pyelonephritis, prostatitis, and male and female gonorrhoea.
  • Gastro-intestinal tract: Typhoid and paratyphoid fevers, chronic carriage of Salmonella typhi and S. paratyphi, cholera and shigellosis.
  • Skin: Pyoderma, abscesses and wound infections.
  • Others: Acute and chronic osteomyelitis, acute brucellosis, septicemia and other infections caused by susceptible organisms.
Contraindications
Use only under the supervision of physician for children under 3 years.
It is contraindicated in the following:
  • Hypersensitivity to its two components.
  • Patients showing marked liver parenchymal damage.
  • Severe impairment of renal functions.
  • Premature infants or full-term infants of less than 6 weeks postnatal age.
  • Pregnancy and serious hematological disorders.
Drug Interactions
Co-administration of Septazole with the following drugs is not recommended:
  • Primethamine
  • Oral hypoglycemics
  • Phenytoin
  • Warfarin
Side Effects/Adverse Effects
Septazole is well tolerated at the recommended dosage, but sometimes the following symptoms may occur: Nausea, vomiting, diarrhea and skin rash.
Pregnancy & Lactation
Dosage & Administration
As directed by the physician, or as follows:
Tablets
  • Adults: 2 tablets twice daily.
  • Children (6-12 years old): 1 tablet twice daily.
Suspension
  • Children under 2 years old:  1/2 teaspoonful twice daily.
  • Children 2-6 years old: 1/2 - 1 teaspoonful twice daily.
  • Children 6-12 years old: 1-2 teaspoonful twice daily.
Overdosage
Warnings
Care should be taken in elderly patients due to their reduced intake of dietary folate.
If exanthema develops during treatment with Septazole, the drug should be discontinued.
In cases of renal impairment, the dosage should be reduced to avoid accumulation of the drug.
Continuous supervision of patients during treatment allows early discovery of dangerous side effects as dermatitis, anemia or hepatotoxicity.
Notes
Storage
Packaging
The following product forms are available:
  • Pack containing 2, 20 or 100 strips of 10 tablets.
  • Bottle of 100 or 120 ml suspension.
Manufacturer
Alexandria Co. for Pharmaceuticals
Price
Date Added/Updated
6th April 2011 7:17 am

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