Generic Name
Metronidazole and Diloxanide furoate
Gastrointestinal System
Metronidazole...............200 mg
Diloxanide furoate.........250 mg
Suspension (5 ml):
Metronidazole...............200 mg
Diloxanide furoate.........100 mg
Furazol is a well-tolerated formulation of diloxanide furoate and metronidazole, highly effective in the treatment of intestinal and extraintestinal amoebic infections.
Diloxanide is a luminal amoebicide acting on the amobae in the lumen of the bowel.
Metronidazole has well-established bactericidal activity and is highly effective agaisnt anaerobic bacteria and protozoa; it is a tissue amoebicide, affecting the parasite in the intestinal wall or other organs. In amoebiasis, metronidazole acts as an amoebicide at all sites of infections with Entamoeba histolytica. Because of its rapid absorption, it is probably less effective agaisnt parasites in the bowel lumen and is therefore used in combination with a luminal amoebicide, such as diloxanide furoate, in the treatment of invasive amoebiasis.


Both diloxanide furoate and metronidazole benzoate after oral intake, are hydrolysed in the gastrointestinal tract to release diloxanide and metronidazole, respectively. The free diloxanide acts directly as an amoebicide. The resulting compounds are then absorbed. Metronidazole is widely distributed in most body tissues and fluids and is metabolized in the liver by side chain oxidation and glucuronide fomration. The majority of a dose is excreted in the urine, mainly as metabolites; a small amount appears in the faeces.
Furzol is indicated in:
  • Acute amoebic dysentery.
  • Acute and chronic intestinal amoebiasis.
  • Extra-intestinal amoebiasis; hepatic and other systemic infections due to Entamoeba histolytica.
  • Giardiasis.
Hypersensitivity to the product.
Drug Interactions
The following interactions have been reported:
  • When given with alcoholic beverages, Furazol may produce a disulfiram-like reaction with abdmonial cramps, nausea, vomiting, headache, flushing and palpitations.
  • Metronidazole impairs the metabolism or excretion of warfarin and other oral coumarin anticoagulants; it increases blood levels of these agents, resulting in prolongation of prothrombin time.
  • Co-administration with drugs increasing liver enzyme activity, such as phenytoin or phenobarbital, may accelerate the elimination of metroniazole resulting in reduced plasma levels, with a consequent reduction in the effectiveness of Furazol.
  • Simultaneous administration of drugs that decrease liver enzyme activity, such as cimetidine, may prolong the half-life and increase plasma concentrations of metronidazole and might increase the risk of neurological side effects.
Side Effects/Adverse Effects
Occasional mild gastrointestinal disturbances, flatulence, nausea, vomiting, metallic taste, headache, ataxia, urticaria, angioedema and darkening of urine may occur.
Pregnancy & Lactation
The drug should be avoided during pregnancy, especially during the first trimester. Furazol should be avoided by nursing mothers.
Dosage & Administration
The following dosage is recommended:
  • Adults: 2 tablets 3 times daily for 5-10 days.
  • Children (2-5 years): One teaspoonful (5 ml) 3 times daily for 5-10 days.
  • Children (5-12 years): Two teaspoonfuls (10 ml) 3 times daily for 5-10 days; or 0.5-1 tablet 3 times per day.
Furazol should be avoided in children less than 2 years of age.
There is no specific antidote for overdosage. Gastric lavage and symptomatic treatment are recommended.
Patients should be advised to complete the course, and not to drink alcoholic beverages while taking Furazol.
Clinical and laboratory monitoring is advised in patients receiving prolonged (>10 days) or intensive treatment with Furazol.
Doses should be reduced in elderly and in patients with severe hepatic impairment.
  • Store at a temperature not exceeding 30°C.
Furazol is available in the following packages:
  • Tablets: Blisters of 10 tablets each. Boxes of 20, 30 or 1000 tablets each.
  • Suspension: Bottles of 100 ml.
Date Added/Updated
17th March 2011 5:19 pm


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