Tradename
Dermazin
Generic Name
Silver Sulfadiazine
Category
Topical Preparations
Form
Cream
Composition
Each 100 g contains:
Micronized Silver Sulfadiazine (in hydrophilic base).......1 g
Description
For skin burns.
Properties/Actions
Dermazin cream is a local chemotherapeutic for prevention and treatment of burn wound infections. It limits spreading of the necrosis into deeper layers of the skin and promotes healing of the burnt surface. Silver sulphadiazine disintegrates in the tissue exudates. The silver ion binds to the deoxyribonucleic acid and kills microorganisms, yet it does not affect the cells of the skin and subcutaneous tissue. Sulphadiazine hinders the growth of sensitive bacteria and part of it is also absorbed from the surface. It penetrates into the necrotic tissue and the rather rich exudates. This effect is very important since the systemically applied antibiotic does not affect the burn necrosis which is excluded from the blood flow.
Dermazin cream exerts a broad-spectrum antibacterial action including numerous gram-positive and gram-negative bacteria, especially Peudomonas aeruginosa, Proteus sp., Eshcherichia coli, Klebsiella sp., as well as, some fungi, e.g. Candida albicans, Phycomycetes and Aspergillus sp. Due to its double mechanism of action there is little possibility of development of resistant strains.
Indications
Treatment and prevention of burn wound infections and infected dermal defects, including bed sores and deep neglected wounds.
Contraindications
Dermazin cream is contraindicated in premature and newborn infants, because of the possibility of kernicterus.
It is also not recommended in pregnancy. It should be applied only in cases where the burnt area covers more than 20% of the total body surface, or if the benefit of Dermazin for the burnt patient is greater than the possible risk to the fetus.
Drug Interactions
Side Effects/Adverse Effects
In prolonged treatment of large burnt areas, serum concentrations of sulfonamides may reach values typical of those in systemic therapy (8 to 12 mg%). As the same unfavorable side effects are possible as in general application of sulfonamides, the concentrations of sulfonamides in serum have to be under control during the therapy. Such control is required also in cases of severe renal and hepatic impairments.
Pregnancy & Lactation
Dermazin is not recommended in pregnancy. It should be applied only in cases where the burnt area covers more than 20% of the total body surface, or if the benefit of Dermazin for the burnt patient is greater than the possible risk to the fetus.
Dosage & Administration
A 2 to 4 mm thick layer of the cream is spread over the burnt surface. In the case of large burnt surfaces, Dermazin is applied by means of spatula or a gloved hand. Usually a twice daily application of the cream is sufficient, yet the cream may be also applied more frequently. Afterwards, the burns should be covered with sterile gauze and dressed. Prior to each further application of the cream, the wound should be carefully cleanse; this being important as the cream is only effective on a clean surface. The old cream and the secretion products are removed most easily by gentle jet of water or by bathing in antiseptic agents. The application of the cream is painless and the cream leaves no stains on clothes or on bed linen.
Overdosage
Warnings
Great caution is required in cases of hypersensitivity to sulfonamides, as also in patients with inborn deficiency of glucose-6-phosphate dehydrogenase, since hemolysis may occur after an application of the cream to large areas of the body.
Notes
Storage
Packaging
  • Tubes containing 30 g of the cream.
  • Jars containing 250 g of the cream.
Manufacturer
Sandoz
Price
Date Added/Updated
17th April 2011 12:52 am

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