Tradename
Colospasmin Forte
Generic Name
Mebeverine
Category
Gastrointestinal System
Form
Tablets
Composition
Mebeverine hydrochloride...............135 mg
Description
Antispasmodic
Properties/Actions
Properties:
Colospasmin Forte is a musculotropic antispasmodic used in gastrointestinal disorders. It has a direct action on colonic muscular activity, especially in colonic hypermotility. Colospasmin Forte, being entirely a smooth muscle relaxant without atropine-like effects, is not contraindicated in patients with glaucoma or prostatic hypertrophy.
Pharmacokinetics:
Following oral administration, mebeverine is absorbed from the gastrointestinal tract; peak plasma concentrations are achieved within 1-3 hours after dosing. Mebeverine is about 75% bound to plasma proteins, and is completely metabolized by hydrolysis to veratric acid and mebeverine alcohol. The metabolites are excreted in the urine.
Indications
  • Primary irritable colon characterized by persistent diarrhoea, alternating constipation and diarrhoea, abdominal pain and postprandial distention.
  • Secondary irritable colon due to organic lesions such as reginal enteritis, diverticulitis, specific and non-specific inflammations of the gastrointestinal tract.
Contraindications
  • Hypersensitivity to the prodcut.
  • Paralytic ileus.
Drug Interactions

Side Effects/Adverse Effects
Colospasmin Forte has proved to be well-tolerated in therapeutic dose. The side effects are rare; they may include gastrointestinal disturbances, dizziness, headache, insomnia and depression.
In very rare cases allergic reactions have been reported, especially erythematous rash, urticaria and angio-edema.
Pregnancy & Lactation
Though experiments in rats and rabbits have shown mebeverine hydrochloride not to be teratogenic, Colospasmin Forte is better avoided during pregnancy.
Dosage & Administration
  • Adults: one tablet, three times daily, preferebly before meals.
  • Not recommended for children.
Overdosage
There is no specific antidote in case of overdosage. However, gastric lavage and symptomatic treatment are recommended.
Warnings
Colospasmin Forte should be used with caution in:
  • Patients with marked hepatic or renal impairment.
  • Patients with cardiac disorders such as heart block.
  • Antispasmodics, including Colospasmin Forte, are not recommended for the symptomatic treatment of distal intestinal syndrome in cystic fibrosis.
  • Colospasmin Forte is considered to be unsafe in patients with porphyria.
Notes

Storage
Packaging
  • Store at a temperature not exceeding 30°C.
  • Blisters of 10 tablets each.
  • Boxes of 20 or 1000 tablets.
Manufacturer
EIPICO (Egypt)
Date Added/Updated
11th August 2010 7:56pm

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