Tradename
Ganaton 50 mg
Generic Name
Category
Gastrointestinal System
Form
Tablets
Composition
Itopride Hydrochloride 50 mg
Description
Gastroprokinetic agent
Properties/Actions
Mechanism of Action

Ganaton activates gastrointestinal propulsive motility due to its dopamine D2 antagonizing activity and acetylcholinesterase activity. Itropride activates acteylcholine release and inhibits its degradation.

Pharmacodynamincs

Ganaton also has antiemetic action through interaction with D2 receptors located in the chemoreceptor trigger zone.
Ganaton has been shown to accelerate gastric empyting in humans.
The action of Ganaton is highly specifc for the upper gastrointestinal tract. Ganaton does not affect serum gastrin levels.

Indications
Ganaton is used in the treatment of gastrointestinal symptoms of:
  • Function dyspepsia
  • Non-ulcer dyspepsia (chronic gastritis):
    • Sensation of bloating
    • Early satiety
    • Upper abdominal pain or discomfort
    • Anorexia
    • Heartburn
    • Nausea
    • Vomiting
Contraindications
Ganaton is contraindicated in patients with known hypersensitivity to itopride hydrochloride or any of the excipients. Ganaton should not be used in patients in whom an increase in gastrointestinal motility could be harmful, e.g. gastrointestinal hemorrhage, mechanical obstruction or perforation.
Drug Interactions
Metabolic interactions are not expected since Ganaton is primarily metabolized by flavine monooxygenase and not by VYP450. No changes in protein binding have been seen with coadministration of warfarin, diazepam, diclofenac sodium, ticlopidine hydrochloride, nifedipine, and nicardipine hydrochloride. Since Ganaton has gastrokinetic effects it could influence the absorption of concomitantly orally administered drugs. Particular caution should be taken with drugs with a narrow therapeutic index, sustained release or enteric-coated formulations. Anti-ulcer drugs like cimetidine, ranitidine, teprenone and cetraxate do not affect the prokinetic action of itopride. Anticholinergic drugs may reduce the acion of Ganaton.
Side Effects/Adverse Effects
  • Blood and lymphatic disorders
  • Leukopenia and thrombocytopenia
  • Immune system disorders
  • Anaphylactoid reaction
  • Endocrine disorders
  • Increased prolactin levels and gynecomastia
  • Nervous system disorders
  • Diarrhea, constipation, abdominal pain, increased saliva, and nausea
  • Hepato-biliary disorders
  • Jaundice
  • Skin and subcutaneous tissue disorders
  • Rash, redness and itching
Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant women. Therefore, Ganaton should not be used during pregnancy unless the benefits outweigh the potential risks.
There are no known effects of Ganaton on labor or delivery.
Because Ganaton is excreted in milk, and because of the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Dosage & Administration
The recommended dosage of Ganaton for adult patients is 150 mg daily (one tablet 50 mg taken orally three times a day before meals).

The dose may be reduced according to the patient's age and symptoms (see WARNINGS).
Overdosage
There have been no reported cases of overdsoage in humans. in case of excessive overdosage usual measures of gastric lavage and symptomatic therapy should be applied.
Warnings

Notes
  • Safety of this product in children under the age of 16 has not been established
  • In general, appropriate caution should be exercised in the administration and monitoring of Ganaton in e
Storage
Packaging
Ganaton tablets are scored, white, film-coated, and packed in blister packs of 10's.
Manufacturer
Kahira Pharma (Egypt)
Date Added/Updated
30th November 1999 12:00am

Miscellaneous

Share This!

Respected Sites

drugs.com

rxlist.com

rxwiki.com

Need Help?

on-call support