Dostinex

Class: Sexual Enhancement & Fertility
Dosage Form: Tablets
Description: Prolactin inhibitor
Stock: Available
Manufacturer: Pfizer

Composition:

Active Ingredient:
Cabergoline………………..0.5 mg
Excipients:
Lactose and leucine

Properties:

Cabergoline is one of a group of drugs known as prolactin inhibitors, Dostinex prevents or stops lactation (production of milk) by decreasing levels of a hormone known as prolactin. By decreasing levels of prolactin, Dostinex can also restore fertility.

Indications:

Dostinex is used to prevent or stop lactation (production of milk) soon after delivery of your baby or to stop lactation if you are already breast-feeding. Dostinex is also used for other disorders which are due to increased prolactin levels such as, missing or irregular periods, increased milk secretion or infertility; or in men, impotence or decreased libido.

Contraindicatons:

Before taking Dostinex you should tell your doctor if:

  • You are allergic to to ergot alkaloids (e.g. bromocriptine, or any other ingredients).
  • Your liver or kidneys are not functioning properly.
  • You are taking any medicines to treat psychoses (mental disorders).
  • You are taking other medicines, such as antiemetics (e.g. metoclopramide), or certain antibiotics (e.g. erythromycin), or medicines which are used to treat mental disorders or control severe behavioral problems (e.g. Phenothiazines, butyrophenones, or thioxanthenes) or medicines to treat migraine, and ergotamine which is used to prevent or treat bleeding following abortion or after having a baby).
  • You have a history of increased blood pressure, tissue swelling (e.g. swollen ankles, face or hands) and kidney problems during and following prengancy.
  • You have a history of change of mental state during pregnancy or following childbirth
  • You suffer with any cardiovascular (heart and/or blood vessels) disease.
  • You suffer from Raynaud’s syndrome (exposure to cold affects the blood supply to your fingers and maybe toes which may appear pale or blue, you may feel a tingling, numbness or burning of the affected areas)
  • You have a peptic ulcer (you may feel a gnawing pain in the abdomen when you a.re hungry).
  • You suffer with gastrointestinal bleeding (you may notice your stools are black in colour or that you bring up blood when you are sick).
  • You have low blood pressure or are taking medicines to lower your blood pressure.

Side Effects:

While taking your medicine you may experience some of the following side effects:

  • Dizziness/vertigo
  • Constipation
  • Headache
  • Depression
  • Nausea
  • Muscle weakness
  • Abdominal pain
  • Pins and needles
  • Vomiting
  • Nose bleeds
  • Hot flushes
  • Partial loss of sight
  • Increase in heart rate
  • Decreased blood pressure/fainting
  • Tiredness/sleepiness
  • Breast pain
  • Indigestion and other stomach disorders
  • Cramps

Blood pressure should be monitored when you first start treatment.
You should contact your doctor should the side effects become troublesome. Your doctor may decide to temporarily reduce the dose if you have severe side effects, and then gradually increase it again by half a tablet (0.25 mg) each week, (fortnightly). Your side effects should then be reduced or disappear.
If you suffer from any other unwanted effects while taking your medicine, please tell your doctor or pharmacist.

Dosage and Administration:

Dostinex is to be taken by mouth, preferably with meals.

  • To prevent lactation: 1 mg (2 tablets) on the first day after delivery
  • To stop lactation: Half a tablet every 12 hours for 2 days
  • To reduce prolactin levels in other conditions:
    • Dostinex is usually taken one or two times per week (e.g. on Monday or on Monday and Thursday)
    • Initial doses are usually low (half a tablet to one tablet per week). Your doctor will advise you if you need to take more.
    • Dostinex is not recommended for use in patients under 16 years of age
    • If you forget to take your tablet (or part tablet) at the normal time do not worry, take it as soon as you remember

Pregnancy and Lactation:

Pregnancy
You may need to have a pregnancy test to make sure that you are not pregnant before starting treatment. If you become pregnant during treatment, you should stop taking Dostinex as soon as pregnancy is confirmed.

Lactation
You should not take Dostinex if you wish to continue breastfeeding as it will affect lactation (milk production).
You may need to have regular pregnancy tests and smear tests while you receive treatment.

Warnings:

When you start taking Dostinex your reactions may be slower and you should not drive or operate machinery until you know that you are not affected.
If you do not wish to become pregnant, you should use other methods of contraception, your doctor will advise you.

Packaging:

Amber glass bottle of 2 tablets.

Storage:

Store at room temperature, below 25°C.
Dostinex tablets absorb moisture, so you should always replace the cap after taking out the tablets. Do not remove the special granules from the cap and do not transfer your tablets to another container.

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