Class: Topical Preparations
Dosage Form: Cream
Description: Bacetricidal and fungicidal broad-spetrum anti-fungal agent
Each gram contains:
Miconazole nitrate…………..2 mg
Daktarin combines an antifungal activity against the common dermatophytes, yeasts and various other fungi with an antibacterial activity against certain gram-positive bacilli and cocci. Daktarin inhibits the biosynthesis of ergosterol in fungi and changes the composition of other lipid components in the membrane, resulting in fungal cell necrosis. Daktarin has also been proven to be effective in secondary infected mycoses.
Usually, Daktarin acts very rapidly on pruritus, which frequently accompanies dermatophyte and yeast infections. This symptomatic improvement is seen before the first signs of healing are observed. Daktarin cream does not produce detectable blood levels after topical application. Daktarin cream does not stain skin or clothes.
Skin infections due to dermatophytes or yeasts, other fungi such as: Tinea capitis, corporis, manus, barbae, cruris, pedis (athlete’s foot).
Since Daktarin has an antibacterial effect on certain gram-positive bacteria, it may be used in mycoses secondary infected with such bacteria (e.g. in napkin dermatitis).
Daktarin cream is contraindicated in individuals who have shown hypersensitivity to miconazole or another ingredient of Daktarin cream.
Daktarin cream is usually well tolerated. There have been isolated reports of irritation or burning sensation associated with the application of Daktarin cream.
As with all substances applied to the skin, an allergic reaction to miconazole or another ingredient of the cream may occur.
Dosage and Administration:
The following is generally recommended:
- To open the tube unscrew the cap
- Then pierce the seal of the tube by means of the pin on the top of the cap
- Apply some cream to the lesions twice daily
- Rub the cream with your finger into the skin until it has fully penetrated
- The duration of therapy varies from 2 to 6 weeks depending on the localization and the severity of the lesion
- Treatment should be continued at least one week after disappearance of all signs and symptoms
Excessive use can result in skin irritation, which usually disappears after discontinuation of therapy. In the event of accidental ingestion an appropriate method of gastric emptying may be used if considered appropriate.
Pregnancy and Lactation:
Daktarin cream applied topically is not systemically absorbed and can be used during pregnancy and lactation.
If a reaction suggesting sensitivity or irritation should occur, the treatment should be discontinued.
Avoid the introduction of Daktarin cream into the eyes.
General hygienic measures should be observed to control sources of infection or reinfection.
Daktarin cream (containing 20 mg of miconazole nitrate per gram) is supplied in tubes of 15 g.
Store at room temperature.